Tuesday August 3, 2004	Wednesday August 4, 2004	Thursday August 5, 2004
08.00 REGISTRATION /Slides Set Up	08.00 REGISTRATION /Slides Set Up	08.00 REGISTRATION /Slides Set Up
THE EPIDEMIC OF AGEING & IMPACT ON CARDIOVASCULAR HEALTH CARE Setting the Scene: What are the epidemiological issues? Chair: S.Pepe 08.30 1. Gary Andrews (Australia)	CARDIOPROTECTION & SIGNAL TRANSDUCTION 08.30 Chair: Headrick & Widdop 08.30 19. Robert Widdop (Australia) : Vascular /Angiotensin and Angiotensin receptors 09.00 20. John Headrick (Australia) : Myocardial ischemic intolerance with age: The role of purines. 09.30 21. Rui Ping Xiao (USA): Beta-Adrenergic Changes in Aging and Beta-2 Adrenergic Signalling in Protection	ADAPTATION, HYPERTROPHY & DYSFUNCTION: THERAPEUTIC TARGETS Chair: Esler & Ferrari 08.30 24. Roberto Ferrari (Italy): Biological mechanisms of the progression of heart failure. 09.00 25. Masao Endoh (Japan) : A therapeutic agent for heart failure: Effects of Levosimendan 09.30 26. David Kass (USA): Ventricular/arterial coupling with aging: mechanisms and pathophysiologic implications 10.00 27. Murray Esler (Australia) : Neural control of the heart in aging & heart failure
WATCHTOWER HILL MEMORIAL KEYNOTE SYMPOSIUM Chair: G. Andrews 09.00 2. Edward G.Lakatta (USA): Intervening on Cardiovascular Aging in Health to Beat Cardiovascular Disease
VASCULAR FUNCTION Chair: Avolio & Lakatta 09.30 3. Michael O’Rourke (Australia): Fundamentals of arterial hemodynamics in health & aging 10.00 4. Alberto Avolio (Australia): Muscular and elastic arteries: independent effects of aging, hypertension & atherosclerosis. Continues after the break	22. POSTER SESSION 10.00-11.30 (REFRESHMENTS SERVED)
10.30-11.00 REFRESHMENT BREAK	23. EXCURSION 11.30-17.30 AIM: 1. attend to travel related health & rest Minimizing Jet Lag via Sun Exposure) 2. Cultural exchange 3. Opportunity to further informal discussions Tour Bus Departure 11.45 Destination: (within 1.5hr drive distance) Healesville Native Wildlife Park	10.30-11.00 REFRESHMENT BREAK
11.00 5. Douglas Seals (USA): Vascular function, exercise & aging 11.30 6. Zeinab Khalil (Australia): Neurogenic control of the microcirculation in the elderly		Numega Australia OMEGA-3 PUFA & SURVIVAL Chair: McLennan & Pepe 11.00 28. Erik Berg-Schmidt (Denmark) : Clinical overview of fish oil in heart disease. From Populations to Trials 11.30 29. Peter McLennan (Australia) : Arrhythmogenesis & Sudden Cardiac Death
Pfizer Australia CLINICAL CARE REALITIES Chair: O’Rourke & Budge 12.00 7.Gordon Stokes (Australia) Treating systolic hypertension in the elderly; adjunct role for nitrates. 12.30 8.Marc Budge (Australia): Targeting Markers in the Elderly for Intervention. 13.00 9.Jonathan Kalman (Australia): The challenge of defeating atrial fibrillation in the aged.
13.30-14.00 LUNCH		12.00-13.30 LUNCH
Tuesday August 3, 2004	Wednesday August 4, 2004	Thursday August 5, 2004
REMODELLING Chair: Rosenfeldt & Simm 14.00 . 10. Hari S. Sharma (Netherlands): Vascular remodelling during pulmonary hypertension under the influence of chronic airway diseases in ageing men. 14.30 11. Andreas Simm (Germany): Age associated changes of AGE-receptor expression in human heart 15.00 12. Paul Goldspink (USA) IGF and MGF in cardiac repair and remodelling.		Sigma-Tau & International Coenzyme Q10 Association AT THE HEART OF CELLS: MITOCHONDRIA Chair: Bernardi & Di Lisa 13.30 30. Ed Lesnesfky (USA). Ischemia-reperfusion mitochondrial response in aging 14.00 31. Fabio Di Lisa (Italy): Mitochondrial vulnerability to ischemia-reperfusion 14.30 32. Paolo Bernardi (Italy): Mitochondrial permeability transition 15.00 33. Brian O’Rourke (USA): Mitochondrial ion channel function & ROS in life and death 15.30 34. Steven J Sollott (USA): A unifying mechanism for cardioprotection & the impact of aging
15.30-16.00 REFRESHMENT BREAK
GENES TO PROTEINS: EXPRESSION, FUNCTION AND TARGETS Chair: Boheler & Du 16.00 13. Kenneth Boheler (USA): Aging-associated changes in cardiac gene expression in humans 16.30 14. Xiao-Jun Du (Australia): Aging in transgenic animals 17.00 15. Jay M. Edelberg (USA): Aging and TNFa Cardioprotection 17.30 16. Jennifer Van Eyk (USA): Cardiovascular proteomics provide insight into heart failure: mechanisms and clinical application 18.00 17. Tom Prolla (USA): Gene expression in aging: Diet & caloric restriction
		35. OPEN FORUM DISCUSSION & MEETING CONCLUSION 16.00-16.30 16.30 MEETING CLOSURE
18.30 BLACKMORES’ COCKTAIL RECEPTION 19.30-20.00 RECEPTION PRESENTATION 18. Franklin Rosenfeldt (Australia) “Use of antioxidants & other dietary supplements for healthy longevity or clinical therapy” · Forum Discussion 21.00 RECEPTION CLOSURE	18.30 DINNER · Round ‘Dinner’ Table Discussion of Key Issues. 20.30 FUNCTION ENDS