Student research project
Supervisor: Professor Peter Meikle
The Metabolomics Laboratory uses state-of-the-art tandem mass spectrometry to obtain metabolic/lipid profiles from cell and animal models in addition to clinically relevant human samples to develop new approaches to diagnosis, risk assessment and therapy for diabetes and cardiovascular disease.
We have recently identified that phospholipid species containing odd carbon and branched chain fatty acids show a strong negative association with obesity and type 2 diabetes. Previous studies have also identified a positive association between branched chain amino acids and type 2 diabetes. These fatty acid species are metabolically linked to the catabolic pathway of branched chain amino acids and a potentially causal pathway has recently been highlighted using Mendelian randomisation studies. However, we do not understand whether an increase in branched chain amino acids, a decrease in branched chain fatty acids or a combination of both contributes to the development of type 2 diabetes.
Figure: Metabolic pathway linking branched chain amino acids with branched chain fatty acids.
We hypothesis that modulation of the branched chain catabolic pathway linking to the biosynthetic pathway of branched chain fatty acids will influence the onset of insulin resistance.
This project is suitable for a PhD student and we will use cell culture and animal models to investigate the relationship between branched chain amino acids and branched chain fatty acids with insulin resistance, glucose tolerance and type 2 diabetes.
This project has the potential to identify a new therapeutic strategy to prevent insulin resistance and progression to type 2 diabetes.