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Using big data approaches to inform our science

Program leads: Professor Michael Inouye and Dr Anna Calkin

 

The Baker Institute's Bioinformatics and Validation Program aims to build bioinformatics capacity through collaboration (internal and external), support and training.

Our capabilities include the analysis of data and cross-omic integration from diverse technologies, including:

  • genomics
  • epigenomics
  • transcriptomics
  • proteomics
  • metabolomics
  • metagenomics/microbiota.

A diverse set of analytical techniques are employed, including:

  • statistical analysis
  • machine learning
  • network analysis
  • high-dimensional data visualisation
  • design of computational algorithms.

This enables the identification of genetic variants, genes and other biomolecular/organismal entities that differ between conditions, as well as the use of these differences to make disease predictions, infer pathogenesis and identify targets for intervention.