Leaders: Professor Andrew Murphy, Dr Graeme Lancaster, Dr Man Kit ‘Sam' Lee and Dr Helene Kammoun
Cardiovascular disease has now surpassed infection as the leading cause of death worldwide. In our laboratory we are attempting to uncover the mechanisms that contribute to the development of cardiovascular disease and identify aspects of the disease process that can be targeted for therapeutic gain. The major focus of our laboratory is in understanding how the cells of the immune system contribute to the development of cardiovascular disease. Existing work within our laboratory is examining the roles of neutrophils and specific subsets of monocytes in cardiovascular disease, as well as defining how lifestyle factors (e.g. diet, obesity) and other diseases (e.g. autoimmune diseases) trigger increased production of immune cells leading to worsened cardiovascular disease outcomes. Our laboratory also has in interest in mechanisms leading to the development of type 2 diabetes and in applying ‘omics’-based discovery platforms to define the types of lipids that are found within the various different types of cells that make up our immune system.
Within this project we will be examining:
- the role of a protein called interleukin 18 binding protein (IL-18bp) in the development of obesity and metabolic dysfunction.
- whether supplementing the diet with probiotics can prevent the bone destruction that is caused by consuming a diet high in salt.
- the lipid and metabolic changes that occur in immune cells.