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Associate Professor Anna Calkin

BSc(Honours) in Physiology, Monash University | PhD in Medicine, Monash University

Associate Professor Anna Calkin

Head: Lipid Metabolism and Cardiometabolic Disease

Co-Lead: Bioinformatics Discovery and Translation Program

 

Monash University supervisor

University of Melbourne supervisor

Baker Institute Fellow

+61 3 8532 1140

A/Prof Anna Calkin received a National Heart Foundation (NHF) postgraduate scholarship as the top-ranked Victorian candidate to undertake her PhD studies with Monash University at the Baker Institute. She then undertook postdoctoral training at the Australian Centre of Blood Diseases, as the recipient of a NHMRC Peter Doherty Fellowship. A NHF Overseas Training Fellowship then allowed her to pursue her interest in lipid metabolism under the mentorship of Professor Peter Tontonoz, a Howard Hughes Fellow at UCLA. Her work on the novel regulator of the LDL receptor IDOL, defined the IDOL-LDLR recognition sequence, a potential therapeutic target to modulate LDL cholesterol levels, and established its importance in humans. She was promoted to adjunct instructor and became a junior member of faculty during this time. Anna returned to the Baker Institute in 2013, and soon after secured a NHF Future Leader Fellowship.

A/Prof Calkin heads the Lipid Metabolism and Cardiometabolic Disease laboratory, co-leads the Bioinformatics Discovery and Translation Program and plays a leadership role within the Gender Equity and Diversity Committee at the Baker Institute. Her research program takes a systems genetics approach, combining large scale ‘omics datasets from humans and genetic panels of mice with validation in preclinical models, to identify novel therapeutic targets for the prevention of cardiometabolic diseases, with a focus on fatty liver and cardiovascular disease.

A/Prof Calkin has published in high calibre journals including Nature, PNAS, Journal of Clinical Investigation, Circulation and Nature Reviews. She has received funding from the Diabetes Australia Research Trust, CASS, NHF and NHMRC and has ties with industry including CSL Limited and Ionis Pharmaceuticals.

Achievements

  • Member, ACvA Emerging Leaders Committee (2018–ongoing)
  • Australian Atherosclerosis Society Executive Committee Member (2017–2018)
  • National Heart Foundation Future Leader Fellow (2014–2018)
  • National Heart Foundation Overseas Fellow (2009–2013)
  • Sir Laurence Muir Medal for Outstanding Medical Research, Baker Institute (2015)
  • Generation of a novel mouse model of atherosclerosis (L-sIDOL Tg Mouse) deposited with Jackson Laboratories

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