Ms Bethany Claridge
Bethany Claridge completed her Bachelor of Biomedical Science with First Class Honours at La Trobe University. During her Honours year, she utilised a multi-omics (proteomics, transcriptomics) approach to investigate the role of RNA binding proteins in sorting specific miRNAs into cancer-derived extracellular vesicles (EVs), known as shed microvesicles. This work has clear implications for understanding how specific RNAs are packaged within a type of EV, our understanding of RBPs and their RNA binding partners in EVs, and importantly how RBPs regulate the trafficking and function of EVs. For this project she used a novel RNA-bait capture approach with high-resolution and high-accuracy mass spectrometry to identify candidate trafficking proteins. Across the duration of this research, she also utilised a range of biochemistry/molecular biology techniques including non-adherent organoidal cancer cell culture, ultra-centrifugation, density-based fractionation, and nanoparticle tracking analyses.
In 2019, as a recipient of the Australian Research Training Program Scholarship and the Baker Institute Bright Sparks PhD Top Up Award, Bethany continues on in the Molecular Proteomics laboratory as a PhD student at the Baker Institute through La Trobe University. With her experience in cancer cell-derived EVs and intercellular signaling, she is enthusiastic about further unravelling the specific interactions occurring in the micro-environment of diseased and fibrotic tissue, in both cancer and cardiac models, to gain further insight into the molecular mechanisms of disease.