Simon Bond is a Group Leader at the Baker Heart and Diabetes Institute, where he leads a research team investigating the molecular mechanisms underlying mitochondrial, metabolic and cardiovascular diseases. His work focuses on how maladaptive cellular stress responses, particularly the Integrated Stress Response (ISR), drive cardiac dysfunction and systemic metabolic complications. Using innovative tissue-specific mouse models and advanced molecular and metabolic profiling, Dr Bond’s team seeks to elucidate the mechanisms by which persistent ISR activation drives disease progression and identify novel therapeutic strategies to improve cardiometabolic health.

Dr Bond joined the Baker Heart and Diabetes Institute in 2017, where his research integrates pre-clinical and translational proof-of-concept approaches to bridge fundamental discovery with therapeutic development. His research has produced high-impact publications in journals such as Nature Communications, contributed to patent applications, and helped shape emerging strategies aimed at targeting metabolic stress pathways for therapeutic benefit.

Dr Bond has secured approximately $2 million in competitive research funding from major funding bodies including the NHMRC, CASS Foundation, MUNZ, and the Heart Foundation. He also manages the Baker Institute’s Mouse Metabolic Phenotyping Facility and Bioenergetics Core, and holds honorary Senior Research Fellow appointments at Monash University and University of Melbourne. Committed to mentoring the next generation of scientists, Dr Bond supervises PhD and Honours students in advanced molecular, metabolic, and in vivo techniques.