Associate Professor David Ascher
B.Biotech | B.Sci(Hon) | LLB | PhD | MRACI CChem
David Ascher is Head of the Structural Biology and Bioinformatics laboratory at the Baker Institute and in the Department of Biochemistry, University of Melbourne. He is a Director of the Australian Society for Medical Research, an Associate Editor of PBMB and holds honorary positions at Cambridge University, FIOCRUZ, and the Tuscany University Network.
David’s research focus is in modelling biological data to gain insight into fundamental biological processes. One of his primary research interests has been developing tools to unravel the link between genotype and phenotype, using computational and experimental approaches to understand the effects of mutations on protein structure and function. His group has developed a platform of 20 widely used programs for assessing the molecular consequences of coding variants (>350,000 hits per month).
Working with clinical collaborators in Australia, Brazil and UK, these methods have been translated into the clinic to guide the diagnosis, management and treatment of a number of hereditary diseases, rare cancers and drug resistant infections.