Student research project
This project will use existing and collected data to determine normal vascular ageing in children, adolescents and young adults.
Cardiovascular disease (CVD) is the leading cause of death worldwide. Therefore, prevention of CVD is a public health priority and identifying individuals at increased cardiovascular risk is of paramount importance. Importantly, CVD has its roots in childhood and there is mounting evidence that the early years of life play a significant part in influencing behavior in adulthood. Furthermore, while a large body of work has focused on exposure to traditional risk factors, more recent evidence has demonstrated increased CVD risk in vulnerable groups such as patients undergoing cancer therapy.
Vascular ageing, the decline in vascular structure and function often resulting in arterial stiffness, is an integrated marker of overall cardiovascular risk burden on the vasculature over time and is independently related to increased CVD risk. However, currently little is known about the regulation of vascular function in early life/the young, and what indicates increased CVD risk. It is also unknown whether exposure to cancer treatment accelerates vascular ageing in youth or young adult cancer survivors.
This project is suitable for a PhD student.
The Sports Cardiology laboratory has a range of potential projects that aim to assess vascular ageing in youth and young adults. Studies may involve analysis of existing data, as well as collection of data relating to vascular ageing, blood pressure, cardiorespiratory fitness, physical activity measures and others using classical techniques and integrative studies. Prospective candidates are encouraged to contact the supervisors of this project for more details or to discuss options for related research activities.