About the Metabolic and Vascular Physiology laboratory
The Metabolic and Vascular Physiology laboratory addresses important clinical questions across the obesity, diabetes and cardiovascular disease continuum. This work is directed to novel preventive, diagnostic and therapeutic strategies through multidisciplinary approaches combining basic bench-top research with human physiology and investigator-led randomised controlled clinical trials. Our work impacts on patient care and has been published in highly regarded journals.
The laboratory is well known for work on vascular biomechanical properties, as well as guideline influencing studies in exercise research elucidating the mechanisms underpinning the cardiometabolic protective effects of physical activity. Current research directions include identification of novel molecular mechanisms applicable to clinical practice, with a particular focus on:
- the glycemic effects of sugary drink consumption
- activation of brown adipose tissue to combat obesity
- HDL therapies for diabetes and ischemic heart disease
- novel predictors and therapies for acute coronary syndromes
- amelioration of the cardiometabolic consequences of haematological cancers.